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KMID : 1225720200120040599
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Allergy, Asthma & Immunology Research : AAIR
2020 Volume.12 No. 4 p.599 ~ p.607
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Health-Related Utility of EQ-5D in Korean Adults With Chronic Urticaria: Mapping From Urticaria Outcome Measures
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Lee Min-Sang
Yoon Ji-Won
Kim Ji-Woong
Shin Yoo-Seob
Park Hae-Sim
Lee Hyun-Young
Ye Young-Min
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Abstract
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Purpose: A need for useful measures reflective of the socio-economic burden of chronic urticaria (CU) has arisen. To obtain utility estimates for CU, we investigated EuroQol-5-Dimension (EQ-5D) indices according to urticaria control status and urticaria severity.
Methods: In this prospective observational study, we administered patient-oriented questionnaires on EQ-5D and urticaria outcomes, including Urticaria Activity Score over 7 days (UAS7), Urticaria Control Test (UCT), and CU-specific quality of life (CU-QOL). EQ-5D utility index scores were compared according to urticaria control status and disease severity. Conditional process analysis (CPA) was used to map EQ-5D utility scores from UAS7 and UCT.
Results: Greater EQ-5D utility values were obtained in patients with better urticaria control (0.91 ± 0.10 for well controlled CU, 0.84 ± 0.12 for partly controlled, 0.77 ± 0.14 for uncontrolled, P < 0.001). According to CU severity, mean utility values were ranged from 0.746 (severe, UAS7 ≥ 28) to 0.860 (moderate), 0.878 (mild), and 0.953 (urticaria free). CPA suggested that UAS7 was directly correlated with UCT (regression coefficient, ?0.251; 95% confidence interval [CI], ?0.278, ?0.223; P < 0.001) and EQ-5D utility (?0.002; 95% CI, ?0.003, ?0.001; P = 0.007) after controlling for age, sex, urticaria duration, and combined allergic diseases.
Conclusions: EQ-5D values increased with improvement in urticaria control and decreased with urticaria severity. A predictive model mapping EQ-5D utility from UAS7 and UCT scores suggested that EQ-5D can be useful for the pharmacoeconomic evaluation of individualized treatments for CU patients.
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KEYWORD
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Chronic urticaria, control, severity, symptoms, quality of life, EQ-5D, utility index
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